Ooft"When the company stepped up to the fourth dose, they quickly ran into problems as grade 3 and 4 SAEs were observed in patients who received the higher dose of 0.13 mg/kg. This led the trial to drop back down to the third dose level.However, this de-escalation has failed to tame the safety problems as the most recent patient given a dose of 0.08 mg/kg experienced respiratory failure and cardiac arrest, possibly related to MGTA-117, which led to death."
Thankful we have a good understanding Zantrenes safety profile already
Industry news, page-973
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