This is the real kicker here in my books Hottod. the mind boggles when thinking about the possibilities of both Trof & NNZ-2591
The hallmark symptom of hyperphagia (abnormal hunger and excessive eating) is another difference between PW and the other 3 indications. Controlling hyperphagia has been found to be a key goal for PW caregivers. In the preclinical animal testing of NNZ-2591 in PW, at the higher dose, obesity was eliminated and abnormally high insulin levels were reduced to normal (Ref. NEU ASX Ann. 16/02/21). Think about that for a minute.
BTW - around one in 10,000 to 20,000 children are born with the syndrome, so at the high end it's about the same numbers as Retts.
Ann: Investor Presentation, 14 March 2023, page-65
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