Ann: Update on Novartis Agreement, page-849

I am impressed that you took the time ( or maybe knew the answer straight off ) to investigate the sales. I for one was not aware that in 2007 ( 16 years ago ), Si sold some shares. However as you pointed out since then he could have yet he decided not to. Interesting the co-incidence that ever since the new manufacturing protocols, and more succesfull trials including those that achieved primary end points he has not sold any shares.

I don't have any issues either, just pointing out when people say he doesn't care about retail investors - that is not correct. He is one of the biggest holders, and he understands what needs to be done at any expense to reach commercialization of the product, and reap the rewards further down track - rather than have a good share price today and delay or never reach commercialization.

He would feel the pain of todays' share price exactly as we do - but he knows what lies ahead better than any of us do and holds his shares with conviction.