Ann: AVITA Medical to Announce First Quarter 2023 Results, page-64

“Pigment may not always return to the skin after a second degree burn. The severity and depth of the burn, as well as the individual's skin type and genetics, can all affect whether or not pigment will return to the affected area.In some cases, the burn may damage the pigment-producing cells in the skin called melanocytes, which can result in permanent loss of pigment in the affected area. This can lead to hypopigmentation, which is a lighter color of the skin compared to the surrounding area.In other cases, the burn may stimulate the melanocytes to produce excess pigment, leading to hyperpigmentation, which is a darker color of the skin compared to the surrounding area. Hyperpigmentation can also be a result of post-inflammatory response to the burn injury.The likelihood of pigment returning to the skin after a second degree burn can also depend on how well the burn is treated and healed. Proper wound care and treatment can help to minimize scarring and promote skin healing, which can in turn increase the likelihood of pigment returning to the affected area.It is important to note that every individual and burn injury is unique, and the return of pigment to the skin cannot be guaranteed. It is recommended to seek medical attention and follow proper wound care and treatment to promote healing and minimize the risk of complications.”

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