This is IMO an excellent review of iron in brain diseases and gives a lot of support for a safe iron chelator. ATH has patented many different iron chelator patents, not only ATH434. These chelators will be used not only in MSA but in PD, AD, strokes, brain injuries, etc.

It is a free paper: https://onlinelibrary.wiley.com/doi/10.1002/mco2.298


Here is the abstract:

Review

MedComm (2020)

. 2023 Jun 26;4(4):e298.

doi: 10.1002/mco2.298. eCollection 2023 Aug.

Iron homeostasis imbalance and ferroptosis in brain diseases

Haining Long ¹, Wangshu Zhu ¹, Liming Wei ¹, Jungong Zhao ¹

Affiliations collapse

Affiliation

• ¹Department of Diagnostic and Interventional Radiology Shanghai Sixth People's Hospital Afliated to Shanghai Jiao Tong University School of Medicine Shanghai China.

• PMID: 37377861

PMCID: PMC10292684 DOI: 10.1002/mco2.298

Abstract

Brain iron homeostasis is maintained through the normal function of blood-brain barrier and iron regulation at the systemic and cellular levels, which is fundamental to normal brain function. Excess iron can catalyze the generation of free radicals through Fenton reactions due to its dual redox state, thus causing oxidative stress. Numerous evidence has indicated brain diseases, especially stroke and neurodegenerative diseases, are closely related to the mechanism of iron homeostasis imbalance in the brain. For one thing, brain diseases promote brain iron accumulation. For another, iron accumulation amplifies damage to the nervous system and exacerbates patients' outcomes. In addition, iron accumulation triggers ferroptosis, a newly discovered iron-dependent type of programmed cell death, which is closely related to neurodegeneration and has received wide attention in recent years. In this context, we outline the mechanism of a normal brain iron metabolism and focus on the current mechanism of the iron homeostasis imbalance in stroke, Alzheimer's disease, and Parkinson's disease. Meanwhile, we also discuss the mechanism of ferroptosis and simultaneously enumerate the newly discovered drugs for iron chelators and ferroptosis inhibitors.