Patents last for 20 years (plus extensions)
Patent chains are updated for improvements is manufacturing, material composition, application etc
Patents can also have their term extended in many jurisdictions by at least the time it took to settle the patent, but up to 5 years.
Trade secrets are real. I know some pretty smart folk who's patents have a spanner here and there to make building from the patent impossible without putting the time and effort into reverse engineering the product the hard way..
I reckon we're good until at least the mid 2030's (based on the patent chain below), though I expect the product will have many improvements and iterations along the way; extending patents much further.
Fes
BTW... Integra's initial lead patent for the scaffold was approved in 1996
INTEGRA PATENT
Patent number: 5489304Abstract: The present invention relates to a method of skin regeneration of a wound or burn in an animal or human. This method comprises the steps of initially covering the wound with a collagen glycosaminoglycan matrix, allowing infiltration of the grafted GC matrix by mesenchymal cells and blood vessels from healthy underlying tissue and applying a cultured epithelial autograft sheet grown from epidermal cells taken from the animal or human at a wound free site on the animal's or human's body surface. The resulting graft has excellent take rates and has the appearance, growth, maturation and differentiation of normal skin.Type: GrantFiled: April 19, 1994Date of Patent: February 6, 1996Assignees: Brigham & Women's Hospital, Shriners Hospital for Crippled Children, Massachusetts Institute of Technology, Integra LifeSciences, CorporationInventors: Dennis P. Orgill, Charles E. Butler, Mark Barlow, Scott Ritterbush, Ioannis V. Yannas, Carolyn C. ComptonPatents Assigned to Polynovo Biomaterials Pty Limited
Patent number: 10898614Abstract: There are provided tissue repair laminates which promote cellular in-growth but also prevent or mitigate tissue adhesion. The laminates comprise a biodegradable polyurethane foam layer which facilitates cellular infiltration and a polyurethane barrier layer which is non-adhesive to tissue. The laminates resist shrinkage under in vivo conditions and possess desirable mechanical properties. The laminates find use in, for example, the repair of herniated tissue, particularly, but not limited to hernias in the abdominal wall.Type: GrantFiled: December 21, 2018Date of Patent: January 26, 2021Assignee: POLYNOVO BIOMATERIALS PTY LIMITEDInventor: Timothy Graeme Moore Patent number: 10844158Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.Type: GrantFiled: June 1, 2017Date of Patent: November 24, 2020Assignee: POLYNOVO BIOMATERIALS PTY LIMITEDInventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari Patent number: 9695268Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.Type: GrantFiled: December 17, 2014Date of Patent: July 4, 2017Assignee: Polynovo Biomaterials Pty LimitedInventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari Patent number: 9540478Abstract: This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.Type: GrantFiled: April 14, 2015Date of Patent: January 10, 2017Assignee: POLYNOVO BIOMATERIALS PTY. LIMITEDInventors: Timothy G. Moore, Raju Adhikari, Pathiraja Arachchillage Gunatillake Publication number: 20150246994Abstract: This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.Type: ApplicationFiled: April 14, 2015Publication date: September 3, 2015Applicant: Polynovo Biomaterials Pty LimitedInventors: Timothy G. Moore, Raju Adhikari, Pathiraja Arachchillage Gunatillake Patent number: 9084827Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: GrantFiled: December 6, 2013Date of Patent: July 21, 2015Assignee: Polynovo Biomaterials Pty LimitedInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake Patent number: 8729202Abstract: The present invention provides a biocompatible polymer composition for use in biomedical applications comprising a base molecule, a linker molecule and at least one initiator compound, said base molecule having at least two differing functionalities, and said linker molecule having a functionality reactive with at least one functionality of said base molecule, the first of said at least two functionalities of said base molecule enabling a first curing stage of said polymer composition by reaction with said linker molecule, and the second and any further functionality of said base molecule enabling second and further curing stages of said polymer composition, said first, second and any further curing stages being capable of activation simultaneously or independently of each other as required.Type: GrantFiled: March 3, 2005Date of Patent: May 20, 2014Assignee: Polynovo Biomaterials Pty LimitedInventors: Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Pathiraja Arachchillage Gunatillake Publication number: 20140099277Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: ApplicationFiled: December 6, 2013Publication date: April 10, 2014Applicant: POLYNOVO BIOMATERIALS PTY LIMITEDInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake Patent number: 8628761Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: GrantFiled: October 31, 2012Date of Patent: January 14, 2014Assignee: Polynovo Biomaterials Pty LimitedInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake Patent number: 8529880Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: GrantFiled: October 31, 2012Date of Patent: September 10, 2013Assignee: Polynovo Biomaterials Pty LimitedInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake Publication number: 20130150964Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: ApplicationFiled: October 31, 2012Publication date: June 13, 2013Applicant: POLYNOVO BIOMATERIALS PTY LIMITEDInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake Patent number: 8445581Abstract: The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.Type: GrantFiled: August 2, 2007Date of Patent: May 21, 2013Assignee: Polynovo Biomaterials Pty LimitedInventors: Pathiraja Arachchillage Gunatillake, Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Heng Chy Taing, Tam Phuong Thi Le, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Jacinta Frances White, Tracy Ann Tebb Publication number: 20130121969Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: ApplicationFiled: October 31, 2012Publication date: May 16, 2013Applicant: POLYNOVO BIOMATERIALS PTY LIMITEDInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake Patent number: 8343472Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: GrantFiled: July 23, 2003Date of Patent: January 1, 2013Assignee: Polynovo Biomaterials PTY LimitedInventors: Raju Adhikari, Pathiraja A. Gunatillake Publication number: 20110287102Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering. The chain extenders comprise a compound of formula.Type: ApplicationFiled: June 20, 2011Publication date: November 24, 2011Applicant: Polynovo Biomaterials Pty LimitedInventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari Patent number: 7964696Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.Type: GrantFiled: September 20, 2006Date of Patent: June 21, 2011Assignee: Polynovo Biomaterials Pty LimitedInventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari Publication number: 20090324675Abstract: The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.Type: ApplicationFiled: August 2, 2007Publication date: December 31, 2009Applicant: POLYNOVO BIOMATERIALS PTY LIMITEDInventors: Pathiraja Arachchillage Gunatillake, Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Heng Chy Taing, Tam Phuong Thi Le, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Jacinta Frances White, Tracy Ann Tebb
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