Ann: Imugene B Cell & OV Platforms Featured at ESMO Congress, page-4

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    Highlights and conclusions

    • Intratumoral (IT) treatment with CF33-hNIS-anti-PD-L1 is safe and well-tolerated
    at dose levels 1 through 3.
    IMUGENE LIMITED ACN 009 179 551 3

    • CF33-hNIS-anti-PD-L1 IT injection induces tumor infiltration of CD4+ and CD8+ Tcells which are critical immune cells signalling localised immune activation
    connected to CF33-hNIS-anti-PD-L1 injection.

    • Significant upregulation of PD-L1 within the tumor microenvironment (TME) further
    suggests immune activation by CF33-hNIS-anti-PD-L1, an important precursor for
    immune clearance of tumors.

    • SPECT imaging after treatment with CF33-hNIS-anti-PD-L1 showed enhancement
    at injected lesions in 75% of patients, suggesting local viral replication and hNIS
    expression. This shows successful tracking of viral replication using non-invasive
    imaging studies.

    Is it time to insert the rocket emojis? biggrin.png Please lord have mercy on our SP and let this be the bottom and the start of a new upward trajectory! GLTAH
 
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