Boffin99 always great to read your posts, but I would like to challenge your statement in regards delays. While there have been some delays, the discovery of cardioprotection and RC220 has thrown the old timeline out the window. On the new critical path we are only running about 4 to 5 months behind schedule. The limiting factor has been the delivery of the engineering batch by Societal of RC220 - this is required for the preclinical tox studies needed for human trials.
While any delay is not good, it is less bad in the case of RC220 as the patent clock has not started yet. Another positive is we have made a discovery that will allow us to significantly speed up the downstream clinical trials which we probably wouldn’t have found if the engineering batch had been manufactured more efficiently. On long complex critical paths with many steps the timelines tend to swing around a lot. If only I had a crystal ball to help see the future it would be so much easier.
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