The Phase I/IIb Nereid Study Is Now Registered, page-5

Blue bit - thanks - of course mesenchymoAngioblast - M C A.

Yellow bit though -year I recall Temple. Do you recall Margaux Hodson-Garns (not sure I'm spelling her name right) paper where different cells - each ipscs - some from CYP a line from CDI etc were cultured and compared for hetergeneity.

I recall even the different batches of the CYP cells varied a bit with each other. ie Complete homogeneity wasn't apparent in the graphics - the graphics did show greater consistency or homogeneity in the CYp cells in different batches with each other than a selection of other sourced cells did - but there were still some differences - some heterogeneity seemed to arise - which I think MHG attributed to the positions of the cells in clusters such that some got more nutrients or cellular signals simply because they were clustered on the outside of a ball of cells versus on the inside of a ball of cells surrounded by their presumed clone sisters.

Not sure there was ever much analysis or exploration or investigation into how different those cells all from CYP but from different batches cultured actually were.

I can easily grant Sally Temple would have nailed lots of sources of variability - but I'm not sure MHG (who actually impressed me with the tone of her PhD that recall reading - she was quite - balanced - not an exaggerating hyper. I don't know if MHG actually explored if there were differences in what different cells from within a Cyp cluster - say some taken from the edge of the ball of cell and some taken from a centre - whether they would make different things?