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    Yes definitely will be a factor in it for sure...this is why some protocols are IBW - Ideal Body Weight, they take the weight of the person into account.


    "The amount of fat tissue in a person’s body increases the distribution space and thereby lowers the serum concentrations of fat soluble medications, which can in turn affect the effectiveness of the drug".



    Ref:
    https://stop.publichealth.gwu.edu/LFD-apr23
 
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