The Envelop protein (E) is very highly conserved within all strains of corona viruses and E is also present in all corona viruses. It is one of the four essential structural proteins.
Here is a little picture to demonstrate the similarity in Sars1, Sars2, and Mers (not MARS as mistakingly written on the diagram) E protein's 75 amino acid structure.
MERS by the way, where the similiarity is least, is not an argument against the conservation of E within corona viruses. All recent strains belong to SARS2. MERS is a different disease from a different corona virus, making it relevent for BIT225, but not in the conservation of E debate. MERS still lives on too. SARS1 only in the lab.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832061/
Even though they've compared SARS 2 to SARS1, SARS1 is not infact SARS2's closest relative. That is RaTG13 from bats, and others in pangolins. The genome does not lie. Remember that?
Regardless, it is the HIGH conservation of E thoughout the virus' evolution that is important for BIT225. It cannot be stressed enough how important this point is if 225 comes home to roost............... Also, switching the world a successful antiviral from a covid vaccination does not require to be mentioned how earth shattering that will become...........
Personally, I believe and hoping that the 'forthcoming successful trial results' for treating Covid 19 are what is going to put Biotron on the map. HIV will then follow. But hey, I've been saying this for exactly 4 years and 9 days: https://hotcopper.com.au/posts/43808854/single
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