The potential for MTX in the orthopaedic area is huge but we need data. DW said that he has been approached by orthopaedic surgeons to use our product in rotator cuff conditions. The failure rate for standard surgery is high especially in the old and frail. Perhaps 40 percent I saw somewhere. So a simple procedure done under ultrasound and X-ray control might be useful. I could envisage MTX being used extensively in bone surgery to promote healing in the frail in cancer bone fractures and in non union of fracture situations as in redo operations etc. Dental implants are another big area. The majority of these are done in the mature population whose bone density is less than ideal so I hope Polynovo could supply some MTX for research and data collection.
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