Even if the treatment works there are risks in doing trials to prove it. A bigger trial hopefully will provide a more accurate result than a smaller trial but...
With more centres involved you have to hope that all the investigators follow the protocols rigidly. With more participants you have to hope that the case mix remains the same as the phase 2 trial. Not all wet AMD is the same and some patients respond better than others. Megan has tried to take care of that by keeping the criteria for patient selection the same and not trying to stack the trial with selected patients that "might" respond better. The phase 2 trial had the best ever recorded response rate to the control treatment, which makes it more likely the phase 3 trial can't be upset by an unusually good control response rate. The statistics for the phase 2 trial were very strong (all the controlled MSB trials have failed to show efficacy by comparison). If you compare the approach of the two companies, Opthea are doing everything right to secure a good result that will get FDA approval if the trials achieve the primary endpoint, Mesoblast have done everything wrong.
Anyway the prize is there if we're lucky enough to have both trials successful. I think you're numbers very much underestimate what would happen should they succeed.
- Forums
- ASX - By Stock
- OPT
- Hang in there!!
Hang in there!!, page-132
-
- There are more pages in this discussion • 30 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add OPT (ASX) to my watchlist
(20min delay)
|
|||||
Last
80.5¢ |
Change
-0.025(3.01%) |
Mkt cap ! $1.021B |
Open | High | Low | Value | Volume |
84.5¢ | 85.0¢ | 80.0¢ | $3.150M | 3.785M |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
9 | 60942 | 80.5¢ |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
81.0¢ | 129155 | 31 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
9 | 60942 | 0.805 |
17 | 162992 | 0.800 |
8 | 49681 | 0.795 |
10 | 293372 | 0.790 |
5 | 494426 | 0.785 |
Price($) | Vol. | No. |
---|---|---|
0.810 | 129155 | 31 |
0.815 | 75920 | 12 |
0.820 | 42979 | 9 |
0.825 | 45332 | 7 |
0.830 | 114757 | 5 |
Last trade - 15.44pm 02/10/2024 (20 minute delay) ? |
Featured News
OPT (ASX) Chart |