I have created this chart to visually represent the universal role Bisantrene plays in cardioprotection against common cardiotoxic chemotherapies. A 1 uM dose of Bisantrene significantly improves HCM viability (p < 0.001). The real value for this opportunity is that while providing cardioprotection, Bisantrene improves cancer cell killing in combination with these chemotherapies. There are already 2 clinical trials where Bisantrene is used in combination with moderately cardiotoxic chemotherapies not listed in the figure below that achieved combined ORR of 46% and 40% with no clinically relevant signs of cardiotoxicity.
A drug with a universal cardioprotection mechanism combined with a universal cytotoxicity mechanism has not existed until now.
Cardioprotection thread, page-518
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