Hi Baldwidx
As already explained by Kryptonite, Neuren’s focus now is on neurodevelopmental rather than neurodegenerative disorders. More specifically, on orphan neurodevelopmental disorders.
Although NNZ-2591 may well be helpful for Lewy body, it’s neither a neurodevelopmental disorder nor an orphan indication.
Down syndrome, which you mentioned, is a more prevalent neurodevelopmental disorder but to meet US orphan disease designation, the US population must be < 200,000 so it’s unlikely that Down syndrome would meet that threshold.
The even more common neurodevelopmental disorders such as autism, ADHD and intellectual disability certainly don’t qualify as orphan indications.
I’m not sure which neurodevelopmental disorder has the highest patient population that still falls below the threshhold for orphan designation. It might possibly be 22q11.2 Deletion syndrome (DiGeorge syndrome).
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