New eye paper by Finkelstein et al

https://www.nature.com/articles/s41598-024-66284-7

This is published in Nature, one of the best journals in the world.

Here is the conclusion:

Conclusions

The current study is the first to examine HSI in a live mouse Parkinsonian retina. Hyperspectral imaging in two mouse PD models show a signature which is similar to an AD mouse model but completely distinct and opposite to that arising from healthy aging. We show preliminary evidence for an association of HSI with retinal levels of α-synuclein and iron. Furthermore, in aging, the integrity of the RNFL may influence HSI. Future studies which more comprehensively examine the biological drivers of PD and age-induced hyperspectral changes will pave the way for HSI as a non-invasive, scalable biomarker for neurodegenerative disease.


I am waiting for this group to publish what ARH434 does to these changes. They seem to have many tools to study these changes.