Thanks @Moreforme,
There is a lot of stuff out there investigating the relationship between autophagy and aging. Mostly relating to fasting, but MPL also induces autophagy. [With very few side effects] The Noble Prize for medicine in 2016 went to a Japanese researcher for his work in this field. It's interesting and worth reading, but lets concentrate on ALS, then someone can explore further down the track.
https://www.nature.com/articles/s43587-021-00098-4#Sec14
https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2019.00308/full#S11
Cheers
PAA, A New Dawn , FDA ODD Approval and Entering Phase II MND Trial, page-852
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