These are promising results, especially point 1, which shows patients receiving the combination therapy had an average survival time that was about 32% greater than those receiving chemotherapy alone.The study investigates the effectiveness of combining standard chemotherapy with endoscopic ultrasound (EUS)-guided phosphorus-32 (^32P) microparticle intra-tumoral implantation in patients with locally advanced pancreatic cancer (LAPC). The researchers aimed to compare this combination therapy with standard chemotherapy alone using a propensity-score weighted analysis (PSWA) to reduce selection bias.
Key Findings:
Overall Survival Improvement:
- The combination therapy group had a significantly longer restricted mean survival time (RMST) within 24 months after chemotherapy initiation. Specifically, an estimated 112 days longer than the chemotherapy-only group (459 days vs. 347 days).
Enhanced Local Progression-Free Time:
- Patients receiving the combined treatment experienced an extended local progression-free time by an estimated 112 days compared to those on standard chemotherapy alone.
Higher Probability of Tumor Downstaging:
- There was a 22.3% higher probability of tumor downstaging in the combination therapy group, suggesting better disease control.
Increased Tumor Vascularity:
- Contrast-enhanced EUS (CE-EUS) assessments showed a significant increase in intra-tumoral vascularity at 4 and 12 weeks post-^32P implantation. This suggests that the combined treatment may enhance the delivery of chemotherapy agents to the tumor by improving microvascular flow.
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