Ann: SPONTAN Final Study Results, page-152

Certainly! Here are some common medications that can be delivered intranasally:

1. Fluticasone - Used for allergic rhinitis and asthma.
2. Naloxone - Used for opioid overdose reversal.
3. Sumatriptan - Used for acute migraine treatment.
4. Desmopressin - Used for diabetes insipidus and nocturnal enuresis.
5. Oxytocin - Used for inducing labor and controlling bleeding after childbirth.
6. Calcitonin - Used for osteoporosis treatment.
7. Budesonide - Used for inflammatory conditions like nasal polyps.
8. Midazolam - Used as a sedative and for seizure management.
9. Fentanyl - Used for pain management, especially in acute or emergency settings.
10. Ketamine - Used for pain relief and sedation, particularly in emergency situations or psychiatric conditions like depression.
11. Zolmitriptan - Another triptan medication used for acute migraine treatment.
12. Estradiol - Used in hormone replacement therapy (HRT) for menopause symptoms.
13. Nicotine (nasal spray) - Used as a smoking cessation aid.
14. Cyanocobalamin (Vitamin B12) - Used in the treatment of B12 deficiency.
15. Corticotropin-Releasing Hormone (CRH) - Used in certain diagnostic tests for adrenal disorders.
16. Oxymetazoline - A decongestant used for temporary relief of nasal congestion.
17. Xylometazoline - Another nasal decongestant similar to oxymetazoline.

    
    

    1. Diazepam - Used for the treatment of acute seizures or epilepsy.
    2. Testosterone - Used for hormone replacement therapy in men with low testosterone.
    3. CGRP Inhibitors (e.g., Zavegepant) - Used for treating acute migraine.
    4. Ephedrine - Used as a nasal decongestant and bronchodilator.
    5. Lorazepam - Used for acute anxiety, sedation, or status epilepticus.
    6. Scopolamine - Used for preventing motion sickness or nausea.
    7. Insulin - Some formulations are designed for intranasal delivery to manage diabetes.
    8. Azelastine - An antihistamine used for allergic rhinitis.
    9. Ketorolac - Used for short-term management of moderate to severe pain.
    10. Melatonin (experimental or compounded) - Sometimes used for sleep disorders or jet lag in some formulations.

    Many of these medications use the nasal route for faster onset or to avoid gastrointestinal degradation, providing a convenient alternative to injections or oral administration.
    
    OK, take out the 4-5 used for nasal problems if you like but there's a still plenty there. And it's an emerging technology.