434 is almost a physiological iron chelator. We need to get approval for it from the FDA after the 201 study. Then there are many new potential indications demonstrated in this huge Chinese review with 1001 references. It is a free paper:https://www.nature.com/articles/s41392-024-01969-z.

Abstract below does not tell much but it is here:

Review

Signal Transduct Target Ther

. 2024 Oct 14;9(1):271.

doi: 10.1038/s41392-024-01969-z.

Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Qin Ru ^{# 1}, Yusheng Li ^{# 2 3}, Lin Chen ^{# 1}, Yuxiang Wu ⁴, Junxia Min ⁵, Fudi Wang ⁶

Affiliations Expand

• PMID: 39396974

PMCID: PMC11486532 DOI: 10.1038/s41392-024-01969-z

Abstract

Iron, an essential mineral in the body, is involved in numerous physiological processes, making the maintenance of iron homeostasis crucial for overall health. Both iron overload and deficiency can cause various disorders and human diseases. Ferroptosis, a form of cell death dependent on iron, is characterized by the extensive peroxidation of lipids. Unlike other kinds of classical unprogrammed cell death, ferroptosis is primarily linked to disruptions in iron metabolism, lipid peroxidation, and antioxidant system imbalance. Ferroptosis is regulated through transcription, translation, and post-translational modifications, which affect cellular sensitivity to ferroptosis. Over the past decade or so, numerous diseases have been linked to ferroptosis as part of their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous system diseases, cardiovascular diseases, and musculoskeletal diseases. Ferroptosis-related proteins have become attractive targets for many major human diseases that are currently incurable, and some ferroptosis regulators have shown therapeutic effects in clinical trials although further validation of their clinical potential is needed. Therefore, in-depth analysis of ferroptosis and its potential molecular mechanisms in human diseases may offer additional strategies for clinical prevention and treatment. In this review, we discuss the physiological significance of iron homeostasis in the body, the potential contribution of ferroptosis to the etiology and development of human diseases, along with the evidence supporting targeting ferroptosis as a therapeutic approach. Importantly, we evaluate recent potential therapeutic targets and promising interventions, providing guidance for future targeted treatment therapies against human diseases.