Nice work, mate. Just take a look around at the number of people who are questioning durability of a response. No idea of the fundamentals for oncology.
The gold standard measure for the FDA is overall survival (OS). This is because without a treatment, patients die. Drugs like Vaxinia are extremely weak, this is evidenced by almost all patients having weak responses (SD) that also rapidly progresses. The CR is the outlier, the mean of the remaining is 100% of the population progressed within 2-3 months.
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