RAC-010: First in-human CPACS Phase 1a/b clinical trial in combination with Doxorubicin, page-16

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    Thanks, mate.

    I can see that RC220 will be dosed before Dox. I am assuming that Bisantrene's mechanisms of protection require it to be dosed before Dox (or chemo generally).

    From my reading, Bisantrene has a long half life and distributes rapidly into tissues.

    1. I suppose I am wondering if work has been completed that has identified the duration of time after Bisantrene dosing required for optimal healthy tissue protection?

    2.a) If this work has been completed, how long does Bisantrene provide a barrier for healthy cells? b) If the prior is too specific a question: is the duration of protection correlated with the half life of Bisantrene?

    I guess I'm really trying to determine whether it is expected for Bisantrene to provide healthy cell protection equivalent to the half life duration of other anti-cancer agents.

 
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