Ann: First Cohort Dosed in Nyradas Phase I Clinical Trial, page-9

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    - No strong blood-brain barrier (BBB) penetration data
    . CEO has stated this in multiple webinars done by the company that it already penetrates the human blood brain barrier and they have this data.

    AGNhas traded at a 70-120 million market cap phase 1 completion and primary brain protection during ischaemic stroke. NYR is primary, secondary brain injury and also protects the heart muscle. AGN only prevents further primary brain injury. The potential and use of NYR is significantly larger. Your 25 million market cap target on phase 1 not at all correct

    Furthermore Phase 2 completion will make this a billion dollar plus drug. Human heart has TRPC 3,6,7 receptors in very high concentrations and mechanism of action of inhibiting calcium influx for primary brain protection is already well proven by NA-1 and AGN which its main mechanism of action is calcium inhibition. Main difference is that glutamate is important for neuron survival during primary brain injury as well and NYR BO3 removes that effect




    Last edited by Bendunstan: 31/03/25
 
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