When we are mostly talking about neurodegenerative diseases, and in particular rare diseases such as MSA, it is not easy to see the big picture of ferroptosis, only "invented" 13 years ago as a new cell death method.

Diseases such as gestational diabetes mellitus, preeclampsia, preterm birth, and miscarriage can be regarded as ferroptosis diseases, but also many female cancers, and endometriosis, polycystic ovary syndrome, etc, can be classified as ferroptosis diseases.

ATH434 could one day be used in these diseases, who knows? It is a long way, but I cannot avoid thinking about this possibility. Some of them can be much easier to study than these slowly progressing neurodegenerative diseases. But ATH needs to find partners for these studies, many of them.

Review

MedComm (2020)

. 2025 Aug 15;6(8):e70296.

doi: 10.1002/mco2.70296. eCollection 2025 Aug.

The Role of Ferroptosis in Women's Health and Diseases

Qiang Xu ¹, Chongying Zhu ², Lin Li ³, Jiayong Li ⁴, Zihao An ¹, Chao Tang ¹

Affiliations Expand

• PMID: 40821694

PMCID: PMC12356996 DOI: 10.1002/mco2.70296

Abstract

Currently, there are many diseases worldwide that seriously affect women's health. Among these, gestational disorders and female cancers such as ovarian cancer are particularly notable for their high morbidity and mortality rates. Over the past decade, ferroptosis, a distinct form of programmed cell death primarily driven by iron-dependent phospholipid peroxidation, has been implicated in the pathogenesis of various female-related diseases. Despite many studies individually reporting that ferroptosis plays a crucial pathogenic role in common female disorders, there has yet to be a systematic overview addressing the mechanisms linking ferroptosis with women's health and disease. Thus, we herein provide a comprehensive review of the relationship between cellular pathways of ferroptosis and women's health and disease and describe the current progress of targeted therapy for ferroptosis. Following a succinct introduction to the disease, we summarize the regulatory role of ferroptosis in women's health and its implications for disease progression, with the aim of facilitating a clearer understanding of the relationship between ferroptosis and women's health. Finally, we discuss the emerging challenges and opportunities presented by various agonists or inhibitors targeting ferroptosis as potential therapeutic strategies for female-related diseases, providing additional protective approaches contributing to female health.


Here is the full paper: https://onlinelibrary.wiley.com/doi/10.1002/mco2.70296