Gassy, they plan to use ATL1102 as a co-agent (mobilization agent), to improve the level of stem cells released when using the agent G-CSF/Mozobil. Potentially it is another easy market for them to tap into fast as the results are very encouraging and they can follow Mozobil under ODA status...
These are the hot points;
“ One such complimentary therapy, MozobilTM, has been approved for use in combination with the main agent G-CSF. First marketed in 2009, MozobilTM sales in 2010 were ~US$100Mill with peak sales potential estimated at US$350Mill per annum. MozobilTM has orphan drug status in the United States and European Union for the mobilization of hematopoietic stem cells. While MozobilTM does boost the number of stems cells released beyond G-CSF alone, a clinical need remains for agents that can improve on the level of stem cell release currently being achieved with the G-CSF/MozobilTM combination. ATL1102 has a novel action (different to both G-CSF and MozobilTM) in targeting the VLA-4 receptor, the blocking of which has been shown to aid in the release of stem cells from the bone marrow. This could see ATL1102 used in place of MozobilTM should it demonstrate clinical superiority, or together with both G-CSF and MozobilTM to enhance their effects.”
“ there is an opportunity to improve on the level of stem cell release achieved with the use of G-CSF alone by the addition of complimentary therapies - the role envisaged for ATL1102.”
“A version of ATL1102 designed to work in mice was used over 7, 10 and 14 days in combination with G-CSF given on the last 3 days of treatment, released one of the recognized stem cells (GEMM cells) up to 13 times more (p<0.01) compared to saline control at day 14, and 7 times more than with G-CSF used alone (p=0.05).”
Certainly sounds impressive.... but in the short term i think ATL1103 results or ATL1101 tie-in deal will take the stage.
But this new application certainly gives more diversity with what our drug range can/will be used for.
Another great day for ANP today. I have a feeling things may really heat up tomorrow... good chance we will break 0.036 before consolidation... then onto the low 4c range probably by December 1 at this rate.
JMO, and Good Luck!
ANP Price at posting:
29.0¢ Sentiment: LT Buy Disclosure: Held
