008 - My Theory, page-16

Hi Mozz,

As you said.....

“The other test to pass is of course the ol' Placebo...and how we compare to it from baseline. We know the high effect of placebo specially when there is a higher degree of pain involved, it is a hurdle we need to cross and consistently we have managed to do that so far. Again 008 will look at this too.”

This is actually the least of my worries in 008 as you can’t trick the Biomarkers into giving you better results. The phase two trial showed that while the recipients of Zilosul improved in the joint (through MRI scans) the placebo patients got worse.

So yes we will have placebo to over come but for me that’s excellent because the results are scientific rather than a “feeling”.

Hopefully (apologies to those patients) the placebo patients show a further degradation of the joint while those with Zilosul show a halting of OA and perhaps regeneration of the joint.

A lot rides on 008 but it’s near term and very exciting.

DYOR and Not advice