Using thismethod of all the bio markers mentioned , is it...

Using thismethod of all the bio markers mentioned , is it conceivable a cure could stillbe seen ?

Yes, it'sconceivable that a cure for HIV could still be seen using biomarker explorationin patients with undetectable viral loads, even though directly measuring viralload wouldn't be effective. Here's why:

• Indirect Evidence of Viral Control: While directly measuring a drop in viral load isn't possible, some biomarkers can provide indirect evidence that BIT225 is impacting the virus. For example, a decrease in the size of the HIV reservoir or a reduction in replication-competent HIV could suggest the drug is limiting the virus's ability to persist and spread.
• Immune System Response: Biomarkers related to the immune system's response to HIV can be informative. An increase in HIV-specific T cells or a decrease in inflammatory markers could indicate that BIT225 is helping the immune system better control the virus. These changes might not directly lead to a drop in viral load because it's already undetectable, but they could be a sign of a more robust immune response that could potentially lead to eradication in the long term.
• Drug Target Engagement: If biomarkers confirm that BIT225 is interacting with its intended target in the body, it strengthens the case for the drug's potential to affect HIV. While this doesn't guarantee a cure, it provides evidence that the drug is working as designed.

Challenges and Considerations:

• Biomarker Specificity: Not all biomarkers are perfect indicators of HIV cure. Some may be influenced by factors other than the drug itself. Careful interpretation of data is crucial.