$10 Billion Deal, page-12564

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fishman67

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17/05/24

17:44

Post #: 73884717
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Originally posted by Fingers xed ↑

Using thismethod of all the bio markers mentioned , is it conceivable a cure could stillbe seen ?
Yes, it'sconceivable that a cure for HIV could still be seen using biomarker explorationin patients with undetectable viral loads, even though directly measuring viralload wouldn't be effective. Here's why:

Indirect Evidence of Viral Control: While directly measuring a drop in viral load isn't possible, some biomarkers can provide indirect evidence that BIT225 is impacting the virus. For example, a decrease in the size of the HIV reservoir or a reduction in replication-competent HIV could suggest the drug is limiting the virus's ability to persist and spread.

Immune System Response: Biomarkers related to the immune system's response to HIV can be informative. An increase in HIV-specific T cells or a decrease in inflammatory markers could indicate that BIT225 is helping the immune system better control the virus. These changes might not directly lead to a drop in viral load because it's already undetectable, but they could be a sign of a more robust immune response that could potentially lead to eradication in the long term.

Drug Target Engagement: If biomarkers confirm that BIT225 is interacting with its intended target in the body, it strengthens the case for the drug's potential to affect HIV. While this doesn't guarantee a cure, it provides evidence that the drug is working as designed.

Challenges and Considerations:

Biomarker Specificity: Not all biomarkers are perfect indicators of HIV cure. Some may be influenced by factors other than the drug itself. Careful interpretation of data is crucial.

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Other than the usual bag of mixed nuts around here at the moment Fingers……..This is why we are here invested in this company and all going well we will be truly well rewarded.
BIT Price at posting: 5.5¢ Sentiment: Buy Disclosure: Held
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$10 Billion Deal, page-12564

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