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“When we designed this trial, we set up arange of different...

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    “When we designed this trial, we set up arange of different outcomes to look at. Some of the markers we set out to measure haven’t shown any differences, while others have shown very significant changes – and these changes clearly indicate that BIT225 is having a unique and significant effect in these subjects. (COMMENT: Remember when Dav kept on harping that the results did not show a statistically significant outcome? He even published graphs! Read on)


    One aspect we set out to measure was whether the addition of BIT225 could improve clearance of HIV-1 from the blood.Current antiretroviral drugs are extremely efficient at rapidly clearing this virus, and the study confirms this. It was not surprising that no additional discernable reductions in blood virus levels were seen with BIT225, but it was important to measure this. But we saw other significant differences that clearly show BIT225 is doing something new and different to these current antiretroviraldrugs.


    “We know that antiretroviral drugs do NOT clear cellular reservoirs. HIV-infected people have to take drugs for their lifetime to keep virus under control. This trial shows for the first time that there may be a way to clear one of the main cellular reservoirs. This is a major step to the ultimate goal of curing HIV-1 infection.”


    The trial was a double-blind,placebo-controlled study undertaken at trial sites in Thailand. A total of 27 HIV infected subjects, who had not previously taken any antiretroviral drugs (COMMENT: This is why the trials were conducted in Thailand. How many treatment naive infected subjects would you find in Australia????),took once daily doses of BIT225 200mg or placebo for 12 weeks in combination with antiretroviral drugs. At the end of 12 weeks, all continued to take antiretroviral drugs as per standard protocols (COMMENT: Not a cowboy outfit as Dav alluded to of trials conducted in Thailand - silly, biased or simply painting the wrong picture for his own ends? You decide.).

    Last edited by mark12: 03/07/19
 
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