Open AccessArticleNew Anti SARS-Cov-2 Targets for Quinoline Derivatives Chloroquine and Hydroxychloroquine†
......not crucial for virus multiplication, the absence of E protein showed an accumulation of probably aberrant virions [78]. Its interaction with PALS1, a particular class of tight junction-associated protein, has been associated with damage to lung epithelium [79]. E protein may represent a novel strategy used by SARS-CoV to increase its virulence [80], and, although it is not involved in the innate immune response to SARS-CoV, it might have an important role in developing a vaccine strategy as well as might be an important target for a chemotherapeutic approach
New paper out of Italy this morning,although focused on Hydroxy,points to the importance of the E-protein as a target for Covid, which (to me) suggests BIT is still on the right track!
