The envelope (E) protein of SARS-CoV-2 assembles into a cation-selective channel that mediates virus budding, release, and host inflammation response. E blockage reduces virus pathogenicity while E deletion attenuates the virus.
These results indicate that SARS-CoV-2 E forms a structurally robust but bipartite channel whose N- and C-terminal halves can interact with drugs, ions and other viral and host proteins semi-independently. This structure establishes the atomic basis for designing E inhibitors as antiviral drugs against SARS-CoV-2.
The PDF link above goes into great detail about examination of the E Protein and how to approach accessing the E Protein for an effective result with Covid 19 - If you haven't already spoken to these researches Michelle Miller - you really should!
BIT Price at posting:
9.4¢ Sentiment: Buy Disclosure: Held
