The following link is to an interview with Roche's Head of Discovery Chemistry, Torsten Hoffmann.
The interview is titled "Exploring Opportunities in Chemical Biology".
http://www.businesswire.com/news/home/20101128005024/en/F.-Hoffmann---La-Roche-Exploring-Opportunities
Hoffmann says pharma need to explore Chemical Biology approaches in much greater detail.
When asked what areas of Chemical Biology, his first reply is:
" One area is certainly the delivery of non-permeable molecules and macromolecules into cytoplasm and into the cell nucleus. What we would have to explore here are active and passive transport mechanisms, endo- or transcytosis, artifical viruses, and cell penetrating peptide motives...."
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Getting drugs into cells seems to be Roche's main focus.
Cell penetrating peptides are what PYC went searching for in stage 1 and PYC are happy with the results.
Roche will give PYC wings.
Cheers ST
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