You need to tackle the main issue here before delving into sub groups. The effects were over the entire population, and were scientifically significant.
No post hoc
No sub group used
MSB then looked at pre specified sub groups including those at high risk of heart disease due high hsCRP, and the diabetic sub group which is categorized often by system wide chronic inflammation.
What they found was an absence of benefit in the absence of inflammation. Since that part of MSC MOA is already known, and already accepted that they are immune modulating amonsgt other things in response to surface receptors that detect inflammation.... The post hoc , pre specified exploratory sub group has allowed MSB to pinpoint which group benefits the most.
It's not a requirement, the effect was big enough on all patients to be scientifically valid, but this particular sub group without inflammation had NO benefit at all.
So... they could be smart and treat those who had benefit.... or they could do what you suggest, and treat the entire population knowing that non inflamed have no evidence of efficacy... because there were 20 subgroups and it could be fluke that non inflamed, had no effect, and therefore complete fluke that inflamed had huge effect and agrees with the moa.
In two separate trials.....
I dont think so.
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