2024 Here we go again., page-523

Yes,

to Clarify these are the numbers

11,000 transplants completed annually, along with baseline immunosuppresants administered.

5,500 of those ( about 50% ), develop aGvHD, with around 1200 being children.

First line approved treatment
Adults recieve "optimised" - ( More ) steroids and immunosupressants.
Children have nothing approved, but may get the same as the adults seeing as nothing is approved.

Second line treatments
Adults recieve anything ( these are not approved either ) , there is not " standard" second line. It could be MSC, different steroids, green tea, Reg's poems, anything.


After completeing the first / second line treatment lines approximately 600 children, and 3000 adults remain as non responders. ( Nothing has worked ).
These are in my opinion the most needy candidates for off label, as without some treatment that works - death will occur.
That would equate to around 2 Billion USD in sales if all 3600 were treated with the pricing assumptions of 400,000 child, 600,000 adult.