Charles Piller's book "Doctored" raises significant questions about existing drugs for Alzeihmers disease (AD). The book highlights the ever increasing need for a safe and effective method of treating and combatting what is now a serious problem facing medical communities worldwide. Xanamem may well provide such an alternative to the flawed treatment options on offer, if indeed Xanamem's phase 2b/3 Trial can once again produce both minimal side effects and sound health benefits in those with elevated pTau levels who are suffering from this debilitating disease. If so the massive chasm now evident in the search for treatment options for Alzeihmers disease may finally be closed somewhat, in a legitimate manner.
As we progress throughout 2025 and Xanamems interim results draw closer there is sure to be more and more eyes on Actinogen. The FDA is going to need to "pull a rabbit out of a hat" when it comes to AD treatment, with Xanamem offering them a potential escape clause, if all goes to plan on the Actinogen front. Meanwhile the existing Amyloid therapies are certain to face further scrutiny at the hands of US regulators who are under the pump as it is, after their European counterparts did not see eye to eye when it comes to this mode of treatment. It's possibly a bridge too far, if not me drawing a long bow, but perhaps Actinogen and therein Xanamem could provide Big Pharma with a much needed scapegoat to fend off reprisals from their previous misgivings in the field of AD research. Let's wait and see on that front. Either way Piller's book is sure to "set the cat amongst the pigeons" as it were in the ensuing months, if not years ahead.
For those wishing to do further reading on the book here's an appraise from the publishers marketing page for "Doctored, Fraud Arrogance and Tragedy in the Quest to Cure Alzeihmer's Disease":
Doctored by Charles Piller https://www.simonandschuster.com/books/Doctored/Charles-Piller/9781668031247
Charles Piller's book "Doctored" Demonstrates how some of the most accomplished and elite scientific gatekeepers may have lied, cheated, squandered trust and endangered lives.” —The Wall Street JournalFor readers ofEmpire of PainandDopesick, an arresting deep dive into how Alzheimer’s disease treatment has been set back by corrupt researchers, negligent regulators, and the profit motives of Big Pharma.Nearly seven million Americans live with Alzheimer’s disease, a tragedy that is already projected to grow into a $1 trillion crisis by 2050. While families suffer and promises of pharmaceutical breakthroughs keep coming up short, investigative journalist Charles Piller’sDoctoredshows that we’ve quite likely been walking the wrong path to finding a cure all along—led astray by a cabal of self-interested researchers, government accomplices, and corporate greed.Piller begins with a whistleblower—Vanderbilt professor Matthew Schrag—whose work exposed a massive scandal. Schrag found that a University of Minnesota lab led by a precocious young scientist and a Nobel Prize–rumored director delivered apparently falsified data at the heart of the leading hypothesis about the disease. Piller’s revelations of Schrag’s findings stunned the field and the public.From there, based on years of investigative reporting, this “seminal account of deceit that will long be remembered” (Katherine Eban, author ofBottle of LiesandVanity Fairspecial correspondent) exposes a vast network of deceit and its players, all the way up to the FDA. Piller uncovers evidence that hundreds of important Alzheimer’s research papers are based on false data. In the process, he reveals how even against a flood of money and influence, a determined cadre of scientific renegades have fought back to challenge the field’s institutional powers in service to science and the tens of thousands of patients who have been drawn into trials to test dubious drugs. It is a shocking tale with huge ramifications not only for Alzheimer’s disease, but for scientific research, funding, and oversight at large."People touched by [Alzheimer's] in any way will want to readDoctored.”
—Bookpage
"[A] gripping story of medical groupthink and warped incentives.”
—The Economist
"'Doctored' demonstrates how some of the most accomplished and elite scientific gatekeepers may have lied, cheated, squandered trust and endangered lives.”
—The Wall Street Journal
"A troubling look at the corruption of Big Science.”
—Publishers Weekly
“Masterfully unfolds an epic tale of astounding fraud, scientific egos run amok, and steely heroism in the pursuit of truth, creating both a page-turner and a seminal account of deceit that will long be remembered alongside Theranos and Enron as a scandal for the ages.”
—Katherine Eban, author,Bottle of Lies, and special correspondent,Vanity Fair
"A riveting must-read master class in science journalism. For those of us who want to ‘trust the science,’ Doctored is the necessary reminder that trust has to be earned.”
—Gary Taubes, bestselling author ofRethinking Diabetes,The Case Against Sugar, andGood Calories, Bad Calories
"A fast-paced ride through a web of scientific misconduct in Alzheimer’s research that has wasted billions of dollars and misled the public.”
—Holden Thorp, editor-in-chief,Science
“Doctored meticulously reveals a world of scientific fraud, its unsuspecting victims, and the sleuths and heroes fighting to fix it. This should be required reading for aspiring scientists, policymakers, and anyone who will one day be touched by a devastating disease—which is all of us.”
—Ivan Oransky, MD, distinguished journalist in residence, New York University, and cofounder ofRetraction WatchOpinions Only
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