Cost-benefit analysis on if to 'spend money' to continue doesn't...

Cost-benefit analysis on if to 'spend money' to continue doesn't mean that science will be your friend also. The one risky thing in bio and why valuations are high on anything positive. You can be an amazing company, do everything perfectly and to a T. Unlike other businesses however where the input (generally) directly relates to outcomes and results, that's not really the case here. You can have a fantastic team, a fantastic well run trial, the results just tell you if you should continue or not. Very few situations where your input doesn't directly influence results in some way.. which is why the risk is so high and so is the reward.

So are we onto a winner (stats would argue nope - most fail) but hey in it to win it with the best team conducting good sound science is all you can do in the bio world and hope science might decide to also be on your side for a win along the way.