44c thank you, page-20

yes fourhofthea, that describes patent 7,615,374, which is outdated.

I'm talking more about these types of patents...
http://www.freshpatents.com/-dt20140918ptan20140273211.php
http://www.freshpatents.com/-dt20130822ptan20130217117.php

eg.
"Current methods for generating iPS cells employ retroviral vectors such as those derived from lentivirus. These vectors stably integrate into, and permanently change, a target cell's DNA at virtually any chromosomal locus. This untargeted interaction between reprogramming vector and genome is associated with a risk of aberrant cellular gene expression as well as neoplastic growth caused by viral gene reactivation (Okita et al. Nature 448:313-317 (2007)).
Moreover, continued presence and expression of the transgenes can interfere with the recipient cell's physiology. Further, ectopic expression of transcription factors used to reprogram somatic cells, such as c-Myc, can induce programmed cell death (apoptosis) (Askew et al., Oncogene 6:1915-1922 (1991), Evan et al., Cell 69:119-128 (1992)). Furthermore, continued expression of factors such as OCT4 can interfere with subsequent differentiation of iPS cells.
It is desirable to reprogram somatic cells to a state of higher potency without altering the cells' genetic makeup beyond the reprogramming-associated alterations. Recently, Stadtfeld et al. generated murine iPS cells using a nonintegrating adenovirus that transiently expressed OCT4, SOX2, KLF4, and c-Myc (Stadtfeld et al., Sciencexpress, Sep. 25, 2008). To date, primate iPS cells generated without using retroviral vectors have not been reported."

and cf. to
http://www.ncbi.nlm.nih.gov/pubmed/19325077
Human induced pluripotent stem cells free of vector and transgene sequences. by Yu et al. (including Slukvin and Thomson).
"Here, we report that human iPS cells completely free of vector and transgene sequences can be derived from fibroblasts by a single transfection with oriP/EBNA1 (Epstein-Barr nuclear antigen-1)-based episomal vectors."



versus CYPs current patent:

"The chimeric hESC lines were generated from two lentiviral constructs: (1) the EGFP protein expressed constitutively from an elongation factor 1 alpha (EF1alpha) promoter, and (2) the H2BB-mOrange protein expressed constitutively from the EF1alpha promoter. Both constructs were packaged in 293FT cells, and the lentiviruses were used to transduce H1 hESCs to produce stable H1 hESC lines that expressed either green EGFP protein or orange H2BB-mOrange protein. Mesenchymal colonies derived from the described methods were of single colors, either green or orange, thus indicating the clonal (i.e., single cell) origin of the MSCs."

Do you guys not see a problem?