" if any have yet been able to cross the brain blood barrier."
"Roche has claimed the latest phase 2 readout for its multiple sclerosis (MS) drug backs up the BTK inhibitor’s "best in disease" potential by achieving the "holy grail" in biopharma: crossing the blood-brain barrier."
Not relevant to what PAB are doing but looks like they are catching up. Link to article below -
Roche BTK inhibitor may show 'holy grail' of brain penetration (fiercebiotech.com)
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