8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
Note: antimicrobial, anti-inflammatory capabilities.
Drug Des Devel Ther. 2013; 7: 1157–1178.
Published online 2013 Oct 4. doi: 10.2147/DDDT.S49763
8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications
Veda Prachayasittikul,1 Supaluk Prachayasittikul,2 Somsak Ruchirawat,3 and Virapong Prachayasittikul1
Abstract
Metal ions play an important role in biological processes and in metal homeostasis. Metal imbalance is the leading cause for many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. 8-Hydroxyquinoline (8HQ) is a small planar molecule with a lipophilic effect and a metal chelating ability. As a result, 8HQ and its derivatives hold medicinal properties such as antineurodegenerative, anticancer, antioxidant, antimicrobial, anti-inflammatory, and antidiabetic activities. Herein, diverse bioactivities of 8HQ and newly synthesized 8HQ-based compounds are discussed together with their mechanisms of actions and structure–activity relationships.
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