NICE UK comments really cut to the chase about bronchitol for CF...
http://publications.nice.org.uk/mannitol-dry-powder-for-inhalation-for-treating-cystic-fibrosis-ta266/consideration-of-the-evidence
Also, taking into consideration the treatment pathway survey provided by the manufacturer in response to the ACD, the Committee acknowledged that mannitol was unlikely to be used in most patients, and that mannitol would be used as an add-on therapy to best standard of care, but not as a replacement for hypertonic saline use in people with stable cystic fibrosis. The Committee also noted that the manufacturer in its response to the ACD proposed that mannitol should only be considered in people with cystic fibrosis for whom hypertonic saline is not appropriate.
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