This literature review, meta-analysis below tells about the global MRSA problem in elderly care centers, It gives also some info about the cost of it and how it will increase mortality. It is self clear that PBT2 could be a good help in controlling this problem as it has ability to reverse antibiotic resistance, the main purpose of the Fund.

Review

Antimicrob Resist Infect Control

. 2023 Jan 29;12(1):4.

doi: 10.1186/s13756-023-01210-6.

The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis

Amir Hossein Hasanpour ¹, Mahdi Sepidarkish ², Abolfazl Mollalo ³, Ali Ardekani ⁴, Mustafa Almukhtar ⁵, Amal Mechaal ⁶, Seyed Reza Hosseini ⁷, Masoumeh Bayani ⁷, Mostafa Javanian ⁸, Ali Rostami ⁹

Affiliations expand

PMID: 36709300 PMCID: PMC9884412 DOI: 10.1186/s13756-023-01210-6Free PMC article

Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a difficult to treat infection, particularly in residents of elderly care centers (ECCs). Despite the substantial burden of MRSA, an inadequate number of studies have analyzed MRSA prevalence in ECCs.

Objectives: We conducted a worldwide systematic review and meta-analysis on the prevalence and risk factors of MRSA in ECCs.

Methods: We searched MEDLINE/PubMed, EMBASE, Web of Science, and Scopus databases and the gray literature sources for all studies published between January 1980 and December 2022 on the prevalence of MRSA in ECCs. A random-effects model was utilized to estimate pooled prevalence rates at 95% confidence intervals (CI). Moreover, the data were analyzed based on World Health Organization-defined regions, income, and human development index levels.

Results: In total, 119 studies, including 164,717 participants from 29 countries, were found eligible for meta-analysis. The pooled global prevalence of MRSA was 14.69% (95% CI 12.39-17.15%; 16,793/164,717). Male gender [prevalence ratio (PR) = 1.55; 95% CI 1.47-1.64], previous MRSA infection (PR = 3.71; 95% CI 3.44-4.01), prior use of antibiotics (PR = 1.97; 95% CI 1.83-2.12), hospitalized within the previous year (PR = 1.32; 95% CI 1.20-1.45), have had any wound (PR = 2.38; 95% CI 2.23-2.55), have used urinary catheter (PR = 2.24; 95% CI 2.06-2.43), have used any medical device (PR = 1.78; 95% CI 1.66-1.91), and those with diabetes (PR = 1.55; CI 1.43-1.67) were more likely to be colonized by MRSA than other patients.

Conclusion: Screening programs and preventive measures should target MRSA in ECCs due to the high global prevalence rates.

Keywords: Long-term care; Methicillin-resistant Staphylococcus aureus; Nursing homes; Residential facilities; Systematic review.

© 2023. The Author(s).