Scottsmy name, You are talking about the paper by Prof Claassen...

Scottsmy name, You are talking about the paper by Prof Claassen (Neurofilament Light Chain and Clinical Progression in Early Multiple System Atrophy) ? This could be the paper to reveal something about the open study despite it being about the natural course of the disease and not about how ATH434 works and changes the natural course.
The abstract says: "Baseline plasma and CSF NfL were independently associated with 6 and 12-month change in total PPS ( a motor severity measure) and UMSARS part 2 (p<0.05). Plasma NfL was additionally associated with 6 and 12-month progression of UMSARS part 1 (p<0.05)".

The open study has no control. We expect that the biomarkers Nfl and alpha-synuclein measurements will improve together with the clinical scores and iron content in the brain.

30% is a good guess at 6 months.

I hope Claassen can say more than the accepted paper. In a way, it would fit very well with the title. We hope the result demonstrates that Nfl increase means worsening the clinical symptoms as is told now in the abstract but a reduction by ATH434 means improvements in the symptoms.