The paper below is written by tens of authors, including Prof. Mark J Walker, one of the 4 patented PBT2, but this publication is not about antibiotic resistance but about how sepsis has become a major cause of death. Of course, antibiotic resistance is a part of this bigger problem and when the abstract lists the most common bacteria causing sepsis, everybody can understand how valuable PBT2 could be in saving lives around the world. These PBT2 commercialization negotiations must come to a solution soon! The world needs it.

Nat Commun

. 2023 Mar 18;14(1):1530.

doi: 10.1038/s41467-023-37200-

Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria



Abstract:

Even in the setting of optimal resuscitation in high-income countries severe sepsis and septic shock have a mortality of 20-40%, with antibiotic resistance dramatically increasing this mortality risk. To develop a reference dataset enabling the identification of common bacterial targets for therapeutic intervention, we applied a standardized genomic, transcriptomic, proteomic and metabolomic technological framework to multiple clinical isolates of four sepsis-causing pathogens: Escherichia coli, Klebsiella pneumoniae species complex, Staphylococcus aureus and Streptococcus pyogenes. Exposure to human serum generated a sepsis molecular signature containing global increases in fatty acid and lipid biosynthesis and metabolism, consistent with cell envelope remodelling and nutrient adaptation for osmoprotection. In addition, acquisition of cholesterol was identified across the bacterial species. This detailed reference dataset has been established as an open resource to support discovery and translational research.



This paper is free: https://www.nature.com/articles/s41467-023-37200-w#Abs1