pubmed.ncbi.nlm.nih.gov /37670159/Exposure to Polystyrene Microplastics Promotes the Progression of Cognitive Impairment in Alzheimer's Disease: Association with Induction of Microglial Pyroptosis - PubMed
Genghuan Wang 1 ,8-11 minutes. 2024 Feb;61(2):900-907.
doi: 10.1007/s12035-023-03625-z. Epub 2023 Sep 5.
Affiliations
- PMID: 37670159
- DOI: 10.1007/s12035-023-03625-z
Exposure to Polystyrene Microplastics Promotes the Progression of Cognitive Impairment in Alzheimer's Disease: Association with Induction of Microglial Pyroptosis
Genghuan Wang et al. Mol Neurobiol. 2024 Feb.
Abstract
We focused on investigating the effects and mechanisms of polystyrene (PS) microplastics in Alzheimer's disease (AD). PS could promote the cognitive impairment in mice and antagonize the action of PS. Meanwhile, it could promote microglial pyroptosis and aggravate neuroinflammation. In vitro results also showed that PS induced pyroptosis of BV2 and RAW264.7, after GSDMD silencing, such pyroptosis was inhibited. Our study found that PS aggravated neuroinflammation by inducing microglial pyroptosis, thereby promoting the progression of cognitive impairment in AD. This finding offers new support and reference for the induction of AD progression by environmental factors.
Keywords: Alzheimer’s disease; Cognitive impairment; Neuroinflammation; Polystyrene; Pyroptosis.
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Similar articles
Han C, Sheng Y, Wang J, Zhou X, Li W, Zhang C, Guo L, Yang Y. Han C, et al. J Cell Physiol. 2022 Oct;237(10):3860-3871. doi: 10.1002/jcp.30839. Epub 2022 Jul 22. J Cell Physiol. 2022. PMID: 35866513
Moonen S, Koper MJ, Van Schoor E, Schaeverbeke JM, Vandenberghe R, von Arnim CAF, Tousseyn T, De Strooper B, Thal DR. Moonen S, et al. Acta Neuropathol. 2023 Feb;145(2):175-195. doi: 10.1007/s00401-022-02528-y. Epub 2022 Dec 9. Acta Neuropathol. 2023. PMID: 36481964
Qian X, Jin P, Fan K, Pei H, He Z, Du R, Cao C, Yang Y. Qian X, et al. Int Immunopharmacol. 2024 Jan 5;126:111307. doi: 10.1016/j.intimp.2023.111307. Epub 2023 Nov 29. Int Immunopharmacol. 2024. PMID: 38035408
Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment.
Knezevic D, Mizrahi R. Knezevic D, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 3;80(Pt B):123-131. doi: 10.1016/j.pnpbp.2017.05.007. Epub 2017 May 19. Prog Neuropsychopharmacol Biol Psychiatry. 2018. PMID: 28533150 Review.
Wang M, Tang G, Zhou C, Guo H, Hu Z, Hu Q, Li G. Wang M, et al. Chem Biol Interact. 2023 Apr 25;375:110387. doi: 10.1016/j.cbi.2023.110387. Epub 2023 Feb 8. Chem Biol Interact. 2023. PMID: 36758888 Review.
References
MeSH terms
- Forums
- Political Debate
- Accelerate the World's Transition to Sustainable Energy - to fight Anthropogenic Climate Change
pubmed.ncbi.nlm.nih.gov /37670159/Exposure to Polystyrene...
- There are more pages in this discussion • 760 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)