acv 1 results mid august, page-6

Hi Needle
your info is usually always spot on and l enjoy your comments however on the latest release l feel that it was a very positive report without overplaying the facts.

1. MBP mentioned they will obtain an independent expert report for analysis and interpretation of the results this may be to detemine EFFICACY also it may also be useful in avoiding any miscommunication that happened last time with their fat pill results so as to ensure credibility to the Market on the whole a good move .

2. MBP has always said their aim of Phase 2A is to determine saftey and tolerability in PATIENTS this is the aim of a phase 2A trial and pharmacodynamic (efficacy )and P.K as well, according to MBPs trial design as the study is exploratory in nature and not powered for analgesia, pain will be assesed in patients by visual analogue scales and appropriate questionnaires Pharmacodynamic measures will include von frey testing and thermal quantitative sensory testing this could be where the independent experts come in and therefore if efficacy has not already been shown there would be no requirement for an idependent report. overall a very positive report coming out within the next few weeks ...