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AGM 2024 - QUESTIONS, page-45

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    Thanks Denial.

    I will be in touch with Paradigm about the trial and some other questions I have.

    From my read the initial phase 3 (oa 11) did not meet primary end points but their extension study oa o7 did meet its primary "objective" and did show structural bhttps://hotcopper.com.au/data/attachments/5746/5746351-3480ba417be02f149ee82ee23ea5197e.jpgenefit over placebo..

    It seems we are obviously way more advanced and our target of KL 3 and 4 is different to where their drug shows most benefit KL2.
    I assume they would also need to start a whole new FDA aproved phase 3. So it kooks like we are good...

    I also noticed another early trial for hand and finger joint OA with another repurposed drug called Talarozole. Different specific indication and early days but worth noting

    https://www.medicalnewstoday.com/articles/new-repurposed-drug-talarozole-hand-osteoarthritis


 
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