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AGM Video, page-3

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    lightbulb Created with Sketch. 808
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    q1 2017 q1 2018 and we go at the q1 2019
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    to be higher again so each of these key
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    ones gets higher our pie chart is still
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    a little bit out of whack typically we
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    would see about 45 percent of the global
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    healthcare business is coming out of
    17:16
    north
    17:16
    whether it's pharmaceutical whether it's
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    medical device across the industry
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    globally obviously billions and billions
    17:22
    in revenue emerging markets typically
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    makes up about twenty to twenty-five
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    I usually includes Latin America Middle
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    East Africa Asia Pacific and then Europe
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    would make up about thirty thirty-five
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    silver in that range so we have a lot of
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    the money coming out of North America
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    but both these segments are growing
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    significant they are and it's important
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    that we actually get that balance right
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    because means all areas are performing
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    as they should one of the things that's
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    important to know is how the cost base
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    has shifted to the US now 2016 a lot of
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    the company was obviously based in
    17:58
    Australia even a therapies infusion and
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    the adaptors it was being run globally
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    out of Australia and that's pretty
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    difficult to do everything else is a
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    long way away the systems in North
    18:09
    America and Europe are completely
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    different and you've certainly need to
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    have that presence the distinction now
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    for us as Minneapolis is in fact the
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    global capital of medical device I grew
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    up in the drug industry which is New
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    Jersey for all the global headquarters
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    for devicive based in Minneapolis why is
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    that important well because when you're
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    dealing with the global headquarters
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    that's how you get deals done all of
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    these folks midtronics and jude boston
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    they're all in their backyard I visit
    18:36
    their campuses we know these people and
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    on the other side we get talent who are
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    floating around these places because if
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    thousands of employees across these
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    companies based in Minneapolis engineers
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    particularly the best in the world the
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    medical engineers there are responsible
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    for creating every device in hospital
    18:52
    these days we have access to those folks
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    all over the place they're good they're
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    relatively inexpensive so it is
    18:58
    absolutely the place to be and because
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    we Minneapolis that's why we've managed
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    to progress out to have our project so
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    quickly and I'll talk about that in a
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    minute but you can also see maybe
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    contrary to popular belief that the head
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    counties are the statical or declining
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    at the point of curb read we had even
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    around 100 we haven't increased our
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    headcount per se we have changed some of
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    those jobs some of them to become more
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    high-value and we certainly shifted
    19:23
    functions to the US that were otherwise
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    not there because they need to be there
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    with 45 percent of that market is the
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    global market and you have to have folks
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    always it connected to that so when you
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    start shifting costs to the US you have
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    two things going on and you'll see this
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    is the full-time equivalents FTE
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    in Australia obviously declining as a
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    percentage of our global head camp
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    obviously going up in the States and
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    everywhere else it's kind of also
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    slightly these are small numbers those
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    percentages don't really matter what's
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    important here is you know people like
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    marketing our chief medical officer dr.
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    brandy who joined us maybe only three or
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    four months ago is an outstanding
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    individual his commercial impact is huge
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    by the way because everything is driven
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    by clinical science and you'll see these
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    costs 2016's TNA costs 2017 2018
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    declining in australia coming up in the
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    states and that's because of that shift
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    but also because of another thing we
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    have an FX impact we probably haven't
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    communicated them a lot because I
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    obviously get emails
    20:26
    positive and negative across the wire
    20:28
    from from any shareholders and you know
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    it's important to keep in mind when we
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    repatriate dollars to the balance sheet
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    in sales we get a benefit obviously US
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    dollars come back into our dollars we
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    get a 30 40 percent lift when we reap it
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    Patriot costs to the balance sheet and
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    the annual report that's going to be
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    reflected a lot higher so when you look
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    at costs in the annual report they
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    recorded as Australian dollars but
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    there's a 40 percent differential
    20:57
    between what we spend and what you read
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    and that's an important distinction
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    doesn't really matter and they doesn't
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    change profitability is still dollars of
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    dollars but the dollar in the US by the
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    same or less than the dollar in
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    Australia costal
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    it was actually higher taxes or about
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    50% so our employees a reflection of
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    that environment plus the 40%
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    differential in FX maybe thank you
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    started this journey we're almost a
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    parody with the with the US dollar here
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    in Australia about 91 92 % which was
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    which was nice but we're always going to
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    carry that but like I said the 45% of
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    the market in the u.s. ultimately will
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    drive up the repatriation of those US
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    dollars back here as well share all the
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    ways there's been a dramatic shift in
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    our shareholder base in the last couple
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    of years and I think one that's really
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    important to understand and one that's
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    beneficial for the company this is as of
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    this month 2019 you can see the total
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    base here we've got obviously star right
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    I'll talk about these two guys in a
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    minute
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    seiyya capital taking up nearly 50% of
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    the register the rest of the top 20
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    fitting in there Levinson and the rest
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    of the investors holding about 44
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    percent of the company we up until this
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    point probably had about 90 percent of
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    our register was held by retail
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    investors that's a good and a bad thing
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    it's not necessarily when you're a
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    company the size of Admetus you need
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    capital this is a global business with a
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    with a big undertaking and big
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    competitors it didn't start life that
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    way survivors immunotherapies and other
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    things but certainly the focus we have
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    now required the support of institutions
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    I would say 90% of the small cap stocks
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    on the ASX in health care that I've
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    invested that I've studied either go
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    broke for lack of capital or they have
    22:46
    massive share price to clients as soon
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    as they start selling stuff because no
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    one's ever fascinated by five million
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    dollars in sales and we follow that same
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    trend when you've got institutional
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    support both these institutions by the
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    way our staff quite doctors the stark
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    folks out of Hong Kong there's a couple
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    of doctors on the board there they
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    invested in science they look at this
    23:05
    company from day one of their investment
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    not as a 10 year old company but as
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    one year or two year old company and
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    they invest accordingly the other
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    important thing is these guys just came
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    on the register in the last few months
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    obviously late last year they're here
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    for the long haul
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    you know we if and when we would need
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    capital these are the folks that give it
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    to us we don't have to necessarily don't
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    want to tap retail investors we simply
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    don't want to focus either but my point
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    is that white-knuckle panic that a lot
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    of small caps go through when they need
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    money wondering where the retail
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    investors can support them is not
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    necessarily something we have to be too
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    concerned about moving forward support
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    from institutions is critical to a
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    company of our size and scale these guys
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    say oh they're based in in New York
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    obviously a little bit about SIA the the
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    principal at SIA is a physician himself
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    he's an ENT surgeon started life as
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    doctor ended up being a banker he
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    invested in us originally was going to
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    be a small amount he invested more and
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    the reason he did that is that he went
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    did his due diligence on our science
    24:10
    with doctors who used that product
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    particularly in New York and other parts
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    of the u.s. doctor the doctor he sat
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    down with him before he made his
    24:17
    investment went through the science came
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    back to me after I think he spoke to
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    about five he spoke to a couple of our
    24:23
    table our doctors as well on our
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    advisory board when we look at the top
    24:27
    20 you can see here it's pretty roughly
    24:29
    evenly split between Starbright that say
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    oh and then 20% make out in those top 20
    24:36
    John mentioned we have moved towards
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    single focus for the company we're
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    bringing a company which is how we
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    started off even at the board when John
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    and I are on the board way back it was
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    very clear the company had to be focused
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    as a as a single focused company
    24:50
    structural hard as it turns out not even
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    know therapies nobody's got a billion
    24:54
    dollars or ten years to bring a drug to
    24:56
    market that's clear and the infusion
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    business whilst it's been a very good
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    business for the company certainly
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    doesn't nestle with our global agreement
    25:05
    moving forward so as you would have seen
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    recently we have been in negotiation for
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    a very long time with BTC on the sale of
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    our infusion business or part of our
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    infusion business
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    and you were seeing that announcement
    25:18
    came out yesterday so we've moved it on
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    or the summit part of that for 6.3
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    million it closes on the 31st of May
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    that's the target of closed date
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    everything being equal that should go
    25:30
    through their full transition will be
    25:32
    the next day we have transition teams
    25:34
    now working to move the reps and the
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    products and all the documents need to
    25:37
    go across to BTC who are publicly traded
    25:40
    listed in Melbourne this will bring
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    about a reduction of about 19% in the
    25:44
    headcount
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    that's the reps and everything else to
    25:46
    go along with that business so there is
    25:47
    obviously a reduction there obviously
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    reduction in the revenue as well we will
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    hang on to the argument missus at the
    25:53
    moment now just for clarity the
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    alchemist is in fact the Royal Adelaide
    25:57
    when we used to talk about that a lot
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    there's about two more years to run out
    26:00
    on that contract and some dollars there
    26:03
    with regards to the consumables we need
    26:06
    to manage that through completion then
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    we have obligations to the Royal
    26:10
    Adelaide so that will remain with us but
    26:12
    in general terms we are now single
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    focused you know humina therapies
    26:16
    obviously that deal fell over after a
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    significant period of time that was
    26:22
    never a balance sheet deal anyway
    26:24
    so whilst we may have got some upside at
    26:27
    the others up the other end if they got
    26:28
    a drugs market we were never getting any
    26:30
    money out of that and that's why I
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    stopped funding at several years back so
    26:34
    here we are we're an adapt company I'll
    26:37
    give you a quick view on the commercial
    26:39
    update I won't spend too much time here
    26:41
    this is now looking at the u.s. the u.s.
    26:44
    is actually growing 55% last year given
    26:47
    the size and scale and it's may be
    26:49
    difficult to appreciate this but the
    26:51
    reps are outnumbered six to one with the
    26:54
    small competitors with the big ones to
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    forget it it's a big number we went to
    27:00
    partner back when I first joined we look
    27:03
    for partnerships people didn't want to
    27:04
    talk to us they didn't know who we were
    27:05
    we had no profile it wasn't enough to
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    have the science unless you have a lot
    27:09
    of doctors using it we now have 20,000
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    patients who have adapt inside that's
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    significant we have a lot of doctors now
    27:16
    supporting us we have a lot of podiums
    27:17
    and more important we have publications
    27:20
    coming out that no other company is even
    27:21
    close to matching in terms of science I
    27:23
    had dinner
    27:23
    with a doctor here who was just going on
    27:26
    about the amount of data that this
    27:27
    company generates relative to the
    27:29
    competitors because he knows them all
    27:30
    obviously feels woman but it's a tough
    27:32
    slog for our represents the point i made
    27:34
    when i when i opened the reps in the
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    state and across the world our
    27:38
    hard-working guys i mean they're girls
    27:40
    they're out there up against a big
    27:42
    number and they're winning the battle i
    27:43
    mean they're growing its data data data
    27:46
    this is a clinical cell that's an
    27:48
    important distinction we have more data
    27:50
    and science than anybody in our science
    27:52
    it's just better and i'll talk about
    27:53
    that again you all know the the key
    27:56
    messages generally but the calcification
    27:58
    that john mentioned is significantly
    28:00
    important and nobody has that and i'll
    28:02
    talk about in a minute but the north
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    america is growing at 67% it's very good
    28:07
    we talk a lot about health systems back
    28:08
    way back when a few years back we have
    28:10
    it signed a few even the health systems
    28:13
    are challenging to work with because
    28:16
    you're dealing with big companies who
    28:18
    have hundreds of millions of dollars of
    28:20
    business with it with the systems who
    28:22
    can offer major discounts which we can't
    28:24
    do and so you're always up against the
    28:26
    size and scale of the other guy but
    28:28
    we're getting there
    28:29
    we launched these 3d products 60 and 30
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    now out in the US there are hundreds of
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    thousands of dollars now generated an
    28:37
    additional revenue that we didn't or
    28:39
    wouldn't otherwise have had that have
    28:40
    come from this portfolio and it
    28:42
    continues to expand of course our
    28:43
    tomorrow project is a 3d product as well
    28:46
    and this this is moving forward quite
    28:48
    quickly we are getting market leadership
    28:51
    in this space in other spaces but what I
    28:55
    heard I had dinner with a surgeon in the
    28:57
    US just a few weeks back an important
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    surgeon does a lot of a lot of
    29:02
    procedures and we were talking about the
    29:04
    competition I was obviously very keen to
    29:05
    know when he sees grips from other
    29:07
    companies what are they saying now
    29:08
    compared to what they're saying two
    29:10
    years ago one of our biggest competitors
    29:12
    whoever's account name had seen him
    29:15
    maybe two or three days before one of
    29:16
    the reps and said we're just as good as
    29:18
    their meters and two years ago they
    29:21
    would never have said that you know
    29:24
    maybe a year ago they would never have
    29:26
    said it but it's a huge comp
    29:27
    they didn't say they were better because
    29:29
    they can't the the most the the best
    29:32
    strategy they had per se which is just
    29:34
    as good which of course is not a
    29:35
    strategy now if you consider the
    29:37
    importance of that over two years just
    29:39
    in two years to get to a point where the
    29:41
    competition who are huge are saying oh
    29:43
    we understand oh it's okay doc we're as
    29:46
    good as those guys it's a huge
    29:48
    compliment Europe again the data is
    29:51
    driving everything in Europe it's very
    29:52
    much a data-driven market we had
    29:55
    challenges in 2016 2017 that's halted
    29:58
    that's the decline in Europe is actually
    30:00
    reversed we're coming back quite
    30:02
    strongly we did have huge delays with
    30:04
    the regulators it actually took 12
    30:06
    months longer than anticipated to get
    30:07
    approval for our 3d products that's
    30:10
    beyond the control of company that's
    30:12
    just the regulator's they blame breaks
    30:14
    it and a whole bunch of other things
    30:15
    because the the EU head for that was
    30:17
    based in the UK whatever it was we got
    30:19
    it over the line end of q1 and we'll
    30:21
    start to see those revenues for 3d
    30:23
    products kick in and we've got a new
    30:24
    team working out their emerging markets
    30:27
    it's quite small for us and we include
    30:30
    Australia in the emerging markets not
    30:32
    because it is one but because
    30:33
    geographically it's placed in and around
    30:35
    APEC which is generally where we
    30:37
    generate business it is growing of
    30:38
    course but off a very small base you
    30:42
    know we expect the TGA some time ago
    30:46
    we were led to believe it was coming
    30:48
    some time ago I'm not going to comment
    30:51
    on a timeline on that one anymore it
    30:53
    bites me every day of the week suffice
    30:55
    to say we've been in close contact with
    30:57
    the TGA they are being supportive I'm
    30:58
    going to Canberra tomorrow to meet with
    31:00
    the people at TGA and hopefully help us
    31:02
    facilitate a an outcome sometime during
    31:05
    next whatever period I won't walk away
    31:08
    with approval tomorrow but hopefully
    31:09
    I'll be able to state our case face to
    31:11
    face which we haven't been able to do
    31:12
    previously so I'm appreciative that
    31:13
    they're meeting with us India that was
    31:16
    obviously a big market we definitely had
    31:19
    some trouble with distributors in India
    31:21
    I don't think it would be super
    31:22
    surprised that it could be a challenging
    31:24
    market I've managed it before and it
    31:28
    just requires a lot of close work and
    31:30
    maybe more resources on the ground that
    31:31
    we could do at the time
    31:32
    we are straightening that out it will
    31:35
    come back to us and we've got a lot of
    31:37
    other approvals coming through we don't
    31:38
    announce them all all the time some of
    31:41
    the bigger markets just came online in
    31:43
    the last week and we'll announce those
    31:44
    but a lot of the smaller markets as well
    31:47
    medical and reg for those that don't
    31:49
    know regulatory affairs in a healthcare
    31:52
    company they're the folks to get you the
    31:54
    approvals the registrations all the
    31:56
    safety monitoring all the things you
    31:57
    need to have this is why you need to
    31:59
    have scientists and doctors and other
    32:00
    people on staff as a medical company
    32:02
    there's no getting out of that so there
    32:03
    are costs there but this is well one of
    32:05
    the things they do obviously is get
    32:06
    approvals and you can just see around
    32:07
    the world what's pending what's in
    32:09
    process so we do have a lot of the 3d
    32:10
    stuff now in process including here
    32:15
    and then we of course save a lot of
    32:16
    markets online predominately Europe and
    32:19
    North America
    32:19
    same with Vaska sill the big markets for
    32:22
    us are here and here
    32:23
    they're online we're working here bit by
    32:25
    bit the the Southeast Asian markets will
    32:28
    also come in line in the coming years
    32:30
    also part of regulatory affairs is
    32:32
    monitoring our clinical studies and it's
    32:35
    important that we understand the
    32:39
    relevance of the studies to our future
    32:40
    revenue and our future strategy these
    32:42
    are costs that we have to win
    32:44
    if we want to become bigger than what we
    32:46
    are today you've got to have data to get
    32:48
    approvals but you remember when we
    32:50
    announced the animal studies about six
    32:53
    months ago eight months ago we started
    32:54
    to implant these 3d valves into sheep
    32:56
    for the first time now this is a 3d
    32:59
    product it's a valve obviously valves
    33:01
    are in a very big space and they form
    33:03
    the core of a Tamara device the rest is
    33:05
    a catheter but what's on the end of that
    33:07
    is the valve before we stick them in
    33:09
    people who go stickmen animals make sure
    33:11
    they work we did them on the bench
    33:12
    obviously now this is a first nobody's
    33:14
    been able to make this 3d valve so
    33:16
    there's one about 3d products we only
    33:18
    started this a couple of years ago I
    33:20
    with John appreciated two years back
    33:22
    that the flat flat patch business was
    33:24
    prestigious but it was never going to
    33:26
    make the family fortune we had to get
    33:28
    into these add alt indications
    33:29
    particularly here this one was X planted
    33:31
    two days ago from the Sheep it's at six
    33:35
    months if you don't quite know what
    33:37
    you're looking at these are the leaflets
    33:39
    of the aortic valve that's the outside
    33:42
    part what's significant about this is
    33:45
    that there is a complete lack of
    33:47
    anything that looks like an adhesion or
    33:49
    calcification which you will see in
    33:51
    these animal models early this thing is
    33:53
    as clean as a whistle so to speak this
    33:57
    is critically important I mean it's it's
    33:59
    hugely valuable for us to see this we
    34:02
    obviously put out some data recently the
    34:04
    EOS or a 2.5 they're much bigger than we
    34:06
    anticipated that's also a very good sign
    34:08
    but when we see them like this ones
    34:09
    we've had to explain them it's amazing
    34:12
    now the professor who did this it's in
    34:15
    Europe we've got normal function after
    34:17
    six months
    34:18
    that means the valves still working as
    34:20
    it should that's important remember
    34:21
    these are juvenile animals so you're
    34:23
    basically taking a healthy valve out of
    34:25
    a one year old
    34:26
    putting in another valve in a patient or
    34:29
    an animal that doesn't need a valve
    34:31
    replacement you have to do that but my
    34:33
    point is when you've got it's already a
    34:34
    healthy animal
    34:35
    you really strut you know it's important
    34:38
    to see those differences when the
    34:40
    animals already healthy and what we're
    34:41
    seeing is a maintenance of that of that
    34:43
    animals health so easily implanted the
    34:45
    surgeons have no trouble putting these
    34:46
    in I was there for the first procedure
    34:48
    in Belgium we have had no failures that
    34:51
    means the valves all worked in the
    34:53
    animals the the gradients are an
    34:55
    important hemodynamic marker no regurge
    34:57
    so these are all important things to
    34:59
    test the valve before we go to man to

 
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