"Patients with new, recurrent or progressive brain metastases are eligible for this trial. Previously obtained tissue from brain metastases and extracranial sites (primary or extracranial metastases) are screened for the presence of these alterations, and if present in both tumor sites, patients will receive the appropriate corresponding targeted treatment."
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Certainly this is very significant information.....brain metastasis original from primary cancers in the body. In these very sick patients, the primary cancers do not just go away. At these great US hospitals, obviously primary cancers would are also monitored closely...of course they would.
We know that in most situations, PI3k mutations in the body spread to the brain, and all these KZA trials are designed to measure response in the brain. Effectively thought, this is a perfect opportunity in a clinical environment, for Pi3k primary cancers to be tested, as they would be in a dedicated breast, lung and skin clinical trial.
This may be the reason, for almost the passing comment by the CEO, recently in a presentation, that GDC 0084 also works outside of the brain.
What I have presented here, just sounds like a typical chatline exaggeration of reality - but how could it be. Why would Dana Farber pass up the opportunity to not fully review primary cancer response, with a PI3k drug they have spoken very highly about.
So primary cancer, high level reviews underway, very probably ......Just another likely major plus for this stock, with its woeful share price.
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