This paper is to be published next summer. Among the authors are Dr. Finkelstein and Dr. Nguyen (ophthalmologist) from Melbourne, Parkville.

IMO, this paper is important because it tells which medical problems beyond AD there are similar as there are in AD. These include cardiovascular disease, cancer, traumatic brain injury, diabetes, glaucoma, retina problems, traumatic brain injury, etc. ATH has been doing preclinical research in many of these problems according to the annual reports. It is a free paper, here is the abstract.

Neural Regen Res

. 2024 Jun 1;19(6):1262-1276.

doi: 10.4103/1673-5374.386406. Epub 2023 Oct 2.

Amyloid-beta and tau protein beyond Alzheimer's disease

Morteza Abyadeh ¹, Vivek Gupta ², Joao A Paulo ³, Arezoo Gohari Mahmoudabad ¹, Sina Shadfar ², Shahab Mirshahvaladi ², Veer Gupta ⁴, Christine T O Nguyen ⁵, David I Finkelstein ⁶, Yuyi You ², Paul A Haynes ⁷, Ghasem H Salekdeh ⁷, Stuart L Graham ², Mehdi Mirzaei ²

Affiliations expand

• PMID: 37905874

DOI: 10.4103/1673-5374.386406Free article

Abstract

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating disease. Physiologically, these two proteins are produced and expressed within the normal human body. However, under pathological conditions, abnormal expression, post-translational modifications, conformational changes, and truncation can make these proteins prone to aggregation, triggering specific disease-related cascades. Recent studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, as well as retinal neurodegenerative diseases like Glaucoma and age-related macular degeneration. Additionally, these proteins have been linked to cardiovascular disease, cancer, traumatic brain injury, and diabetes, which are all leading causes of morbidity and mortality. In this comprehensive review, we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.