Florey group was not the first:

Neurosci Bull

. 2023 Dec;39(12):1775-1788.

doi: 10.1007/s12264-023-01077-y. Epub 2023 Jun 15.

Improving Blood Monocyte Energy Metabolism Enhances Its Ability to Phagocytose Amyloid-β and Prevents Alzheimer's Disease-Type Pathology and Cognitive Deficits

Zhi-Hao Liu ^{1 2 3}, Yu-Di Bai ^{2 3}, Zhong-Yuan Yu ^{2 3}, Hui-Yun Li ^{2 3}, Jie Liu ^{2 3}, Cheng-Rong Tan ^{2 3}, Gui-Hua Zeng ^{2 3}, Yun-Feng Tu ^{2 3}, Pu-Yang Sun ^{2 3}, Yu-Juan Jia ^{2 3}, Jin-Cai He ⁴, Yan-Jiang Wang ^{5 6 7 8 9 10}, Xian-Le Bu ^{11 12 13 14}

Affiliations Expand

• PMID: 37316674

PMCID: PMC10661589 (available on 2024-12-01) DOI: 10.1007/s12264-023-01077-y

Abstract

Deficiencies in the clearance of peripheral amyloid β (Aβ) play a crucial role in the progression of Alzheimer's disease (AD). Previous studies have shown that the ability of blood monocytes to phagocytose Aβ is decreased in AD. However, the exact mechanism of Aβ clearance dysfunction in AD monocytes remains unclear. In the present study, we found that blood monocytes in AD mice exhibited decreases in energy metabolism, which was accompanied by cellular senescence, a senescence-associated secretory phenotype, and dysfunctional phagocytosis of Aβ. Improving energy metabolism rejuvenated monocytes and enhanced their ability to phagocytose Aβ in vivo and in vitro. Moreover, enhancing blood monocyte Aβ phagocytosis by improving energy metabolism alleviated brain Aβ deposition and neuroinflammation and eventually improved cognitive function in AD mice. This study reveals a new mechanism of impaired Aβ phagocytosis in monocytes and provides evidence that restoring their energy metabolism may be a novel therapeutic strategy for AD.